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GUNGOR KARAYALCIN, MD; ALAN SHANSKE, MD; RICHARD HONIGMAN, MD

Am J Dis Child. 1981;135(7):665-667.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Trisomy 18, the second most frequent autosomal trisomy, has an incidence ranging from one per 3,500 to one per 7,000 births.¹ Although survival beyond infancy is unusual,¹ there are a few reports of relatively long-term survivors.^2-4 More than 130 different anomalies have been associated with trisomy 18. Neoplasia, however, is a very rare associated finding. The purpose of this article is to describe a 13-year-old girl with trisomy 18 and Wilms' tumor and to stimulate further interest in the association of aneuploidy and neoplasia.

Report of a Case.—The patient was born on Sept 20, 1966, to a 37-year-old mother. The parents were unrelated. The infant was born two weeks prematurely, weighing 2,530 g. She had multiple anomalies including a congenital heart lesion and had delayed physical and psychomotor development from birth.

On Dec 15, 1977, at age 11 years, an abdominal mass was noted and she . . . [Full Text PDF of this Article]

Author Affiliations
Long Island Jewish-Hillside Medical Center New Hyde Park, NY

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