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KEITH J. SIMONS, PHD; F. ESTELLE R. SIMONS, MD
Faculty of Pharmacy

Department of Pediatrics Faculty of Medicine University of Manitoba Winnipeg, Manitoba Canada R3E OW1

Am J Dis Child. 1981;135(1):83.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.—The slower, initial first-order elimination half-life values are similar in the patient of Kadlec et al¹ and in our much younger patients and seem to indicate saturation of the predominant metabolic pathway. We attributed the slow first-order elimination of methylation, whereas Kadlec et al suggested that first-order renal clearance was apparent. This may not be so, however, since their patient was anuric for ten hours, and there is significant positive correlation between the renal clearance of theophylline and urine flow rate.²

Kadlec et al suggest that no caffeine was found in their patient because of her age. However, Hartemann et al³ have found caffeine in the serum of an 18-month-old infant who ingested 204 mg/kg theophylline, achieving a peak serum concentration of 86 µg/mL. We have shown in our laboratory⁴ that during analysis of caffeine by high-performance liquid chromatography, excessive heating of samples during . . . [Full Text PDF of this Article]

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