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Zehra F. K. Panjvani, MD; James B. Hanshaw, MD

Am J Dis Child. 1981;135(1):56-60.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Cytomegalovirus (CMV) is the most frequent known cause of perinatally acquired infections. Congenital acquisition occurs in 0.5% to 2.7%^1-3 and natal acquisition occurs in 4% to 10%^3,4 of all deliveries. More than 90% of congenitally and natally acquired CMV infections are subclinical. Of infants infected in utero, a substantial percentage have late neurologic sequelae, such as decreased mentation and auditory impairment.^2,3 Not enough studies exist to permit an accurate prediction of eventual outcome among these infants. Nevertheless, CMV is rapidly emerging as the infectious agent most frequently responsible for congenital abnormalities.

HISTORY

The first human strains of CMV were isolated in 1955 by Smith,⁵ from autopsy material of two infants described by Rowe et al,⁶ and by Weller and associates, who isolated the virus from hepatic tissue and/or urine of three living infants with cytomegalic inclusion disease (CID).⁷ Prior to this time, CID was . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Pediatrics, University of Massachusetts Medical School, Worcester.

Footnotes
Reprint requests to Department of Pediatrics, University of Massachusetts Medical School, 55 Lake Ave N, Worcester, MA 01605 (Dr Hanshaw).

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