This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

DAVID A. STUMPF, MD, PhD; MICHAEL FROST, MD

Am J Dis Child. 1978;132(8):746-748.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The JOURNAL has been the forum for previous comments about anticonvulsant teratogenicity.^1,2 High risks are associated with trimethadione.³ The risks associated with other anticonvulsants are less and need to be weighed against the hazards of epilepsy during pregnancy. The conclusion that phenytoin induces serious anomalies in 10% of the offspring of epileptics and less major abnormalities in 30%² is not supported by the bulk of the literature. The recommendation to discontinue such medication in treated epileptics appears unwarranted.

MALFORMATIONS IN CHILDREN OF EPILEPTICS

Most studies are in agreement that epileptic mothers receiving anticonvulsants are two to three times more likely to have malformed infants than mothers who never had a seizure.^4-13 A number of studies indicate that the incidence of anomalous infants is the same in treated and untreated epileptics.^4-6.14 Others find a greater number of anomalies in treated epileptics compared with untreated patients,^8,12,13 . . . [Full Text PDF of this Article]

Author Affiliations
Department of Pediatrics Department of Neurology University of Colorado Medical Center 4200 E Ninth Ave Denver, CO 80262

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?