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GERALD BOTTENFIELD, MD; ENRIQUE M. OSTREA, JR, MD

Am J Dis Child. 1978;132(12):1218-1220.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Neonatal hyperthyroidism is a relatively uncommon disorder. It has been described in infants born to women with active hyperthyroidism and in those born to euthyroid women previously treated medically or surgically for hyperthyroidism.¹ Recent evidence suggests that neonatal hyperthyroidism is due to thyroid stimulation in the fetus by a transplacentally acquired long-acting thyroid stimulation globulin (LATS) or a human specific antibody, LATS-protector (LATS-P), which has been detected in a large number of patients with hyperthyroidism.² Although there have been reports of neonatal thyrotoxicosis, this report is the first to our knowledge to describe its consecutive occurrence in four siblings born to a previously thyrotoxic woman.

Report of Cases.—The mother is a 40-year-old, gravida 6, para 4, abortus 2 woman who was well until 1950 when, at the age of 16, hyperthyroidism developed and she underwent a partial thyroidectomy and a course of iodine 131 therapy. She . . . [Full Text PDF of this Article]

Author Affiliations
Children's Hospital of Michigan 3901 Beaubien Blvd Detroit, MI 48201

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