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HLA Antigens in Mucocutaneous Lymph Node Syndrome
ICHIRO MATSUDA, MD;
SHINZABRO HATTORI, MD;
NORIYUKI NAGATA, MD;
AKIO FRUSE, MD;
HARUO NAMBU, MD;
KATSUKI ITAKURA, MD;
AKEMI WAKISAKA, MD
Am J Dis Child. 1977;131(12):1417-1418.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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Kawasaki disease or mucocutaneous lymph node syndrome (MLNS), first described by Kawasaki1-2 in 1974, is an acute febrile disease of unknown etiology. Until recently, more than 6,000 cases of this disease have been listed in the survey of a special study
 group supported by the Japanese Ministry of Health and Welfare. Although a number of cases have been accumulated even outside of Japan,3-6 it is much less common elsewhere.
The etiology of the disease is now under investigation including the isolation of a Rickettsia-like body.7 There is a possibility that an immunopathological mechanism similar to that of juvenile rheumatoid arthritis and infantile polyarteritis nodosa is responsible, as evidenced by cardiac involvement, increased erythrocyte sedimentation rate, positive C-reactive protein and increased  2-globulin in serum.
Several immunopathological diseases are known to be associated with individual human lymphocytes antigen (HLA),8 but to date no investigation has been
. . . [Full Text PDF of this Article]
Author Affiliations
Department of Pediatrics Kumamoto University Hospital 860 Kumamoto, Japan; Department of Pediatrics Nakanoshima Central Hospital Sapporo, Japan; Department of Pathology Asachikawa Medical College Asachikawa, Japan; Department of Pathology Hokkaido University School of Medicine Sapporo, Japan
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