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Charles A. Alford, Jr., MD; Sergio Stagno, MD; David W. Reynolds, MD

Am J Dis Child. 1975;129(4):455-463.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Clinical diagnosis of perinatal infections in newborns has long been a vexing problem. The causative maternal infections are often asymptomatic (cytomegalovirus [CMV] and Toxoplasma infections), or are so mild as to escape notice (rubella, syphilis, herpesvirus, and enterovirus infections).¹ These, in turn, can result in a wide spectrum of disease in the affected infants. Certainly, some neonates have severe disorders with multiple organ system damage and a fulminant course; however, even in this group, where clinical clues are obvious, similarities among symptoms make specific diagnosis difficult.² To compound the problem further, it has been recognized in recent years that most infections acquired in utero are asymptomatic or too subtle to be recognized in early life.^3-10 In spite of their apparent innocuous nature in infancy, many of them result in serious and irreparable damage not noticeable until long after birth.^5,6,11-17 This is especially true with respect to . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Pediatrics, Medical School, University of Alabama in Birmingham.

Footnotes
Reprint requests to Department of Pediatrics, Medical Center, University of Alabama, University Station, Birmingham, AL 35294 (Dr. Alford).

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