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Felice Caramia, MD; Carlo De Bac, MD; Germano Ricci, MD

Am J Dis Child. 1972;123(4):309-311.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The association of the Australia (Au) antigen with serum hepatitis has been established.¹ The biological nature of the antigen has not been clarified, however, nor has it been proved to be the causative agent of the disease. Electron microscopic studies of the serum precipitate containing the Au-antigen have shown pleomorphic spherical particles of about 200 angstroms in diameter and tubular forms of varying length.² Dane et al³ have demonstrated a double-shelled particle of approximately 400 A in diameter in addition to the smaller round and elongated particles which resemble small viruses. It has been proposed that the large particles are the virus and the smaller particles a reaggregation of virus-proteins.

Millman et al⁴ have shown antigen in liver cells by the direct immunofluorescent technique and Brzosko et al,⁵ using ferritin-labeled antibody, also identified particles of approximately 200 A in thin sections of liver cells from . . . [Full Text PDF of this Article]

Author Affiliations
Rome

From the Laboratorio Biologia Cellulare, CNR (Prof Caramia); and the Clinica delle Malattie Infettive II, dell'Università di Roma (Prof De Bac and Ricci), Rome.

Footnotes
Reprint requests to Clinica Malattie Infettive II, Università di Roma, Policlinico Umberto I, 00161 Rome (Prof Ricci).

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