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Murray Feingold, MD; Robert S. Schwartz, MD; Leonard Atkins, MD; Ronald Anderson, MD; Christos S. Bartsocas, MD; David L. Page, MD; John W. Littlefield, MD

Am J Dis Child. 1969;117(2):129-136.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN CONTRAST to the X chromosome, little is known about the autosomal loci for various genetic traits. Recently Gerald et al1 and Bloom et al² have presented suggestive evidence that the controlling formation of locus the -chain of haptoglobin is situated on one end of a No. 13 chromosome. We have studied two patients with chromosome defects and dysgammaglobulinemia. One had a No. 18 ring chromosome, which is formed by breakage in both arms with reunion of the broken ends and loss of a variable amount of material distal to each break. The other had a partial deletion of the long arm of the same chromosome. In both patients IgA was not detectable, and, in one, the level of IgG was very low. These patients are the first recognized examples of dysgammaglobulinemia associated with a chromosomal deletion.

Report of Cases

Case 1.—A 3-year-old white boy was first admitted to . . . [Full Text PDF of this Article]

Author Affiliations

From the departments of pediatrics (Drs. Feingold, Bartsocas and Littlefield), medicine (Drs. Schwartz and Anderson), and pathology (Dr. Atkins), Tufts University School of Medicine and Harvard Medical School, New England Medical Center Hospitals (Boston Floating Hospital for Infants and Children); James Homer Wright Pathology Laboratories (Drs. Atkins and Page), and Joseph P. Kennedy, Jr., Memorial Laboratories of the Department of Neurology and the Children's Service (Drs. Bartsocas and Littlefield), Massachusetts General Hospital; and the Walter E. Fernald State School (Dr. Bartsocas), Boston.

Footnotes

Presented at the American Society for Clinical Investigation Meeting, Atlantic City, NJ, May 5, 1968.

Reprint requests to 20 Ash St, Boston 02111 (Dr. Feingold).

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