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Samuel O. Thier, MD; David H. Alpers, MD

Am J Dis Child. 1969;117(1):13-23.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

AMINO acids, the primary structural units of proteins, are transported against electrical and concentration gradients across the epithelial cells of the renal tubule and the intestine and across the plasma membranes of most cells. In recent years it has become evident that specific amino acid transport mechanisms in the intestine may be comparable to those in the renal tubule, and may be under the same genetic control. Inherited diseases which directly or indirectly affect these mechanisms are referred to as disorders of amino acid transport. Such disorders were historically discovered as "renal amino acidurias." ("Renal amino acidurias" are a group of disorders in which the capacity of the renal tubules to reabsorb amino acids is reduced [low threshold]. They must be differentiated from two groups of disorders in which known extrarenal enzyme defects produce amino acidurias but in which there are no transport abnormalities. In the first group an . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Renal Unit (Dr. Thier) and the Gastrointestinal Unit (Dr. Alpers), Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston.

Footnotes
Received for publication May 2, 1968.

Submitted by the authors for the Mary Efron Memorial Issue of the JOURNAL.

Reprint requests to Renal Unit, Massachusetts General Hospital, Boston 02114 (Dr. Thier).

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