This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Jerome H. Modell, MD; Bradley E. Smith, MD; H. Denison Williams, BA; Terry C. Weibley, BS; Alfredo Jalowayski, BS

Am J Dis Child. 1968;115(3):322-327.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE USE of fog, generated by ultrasonic nebulizers, has become increasingly popular for the treatment of infants and children with a variety of pulmonary diseases. Recent studies in this laboratory have shown that while dogs tolerate exposure to ultrasonic aerosols for short periods of time (six hours),¹ continuous exposure to aerosols generated from either distilled water or particularly from physiologic saline solution for 72 hours can result in severe pulmonary pathological findings.²

In order to further test the relative toxicity of chronic exposure to various solutions in nebulized form, the mouse, an animal noted for its susceptibility to changes in environment, was selected for the following experiments.

Methods

We divided 800 CBA white mice, averaging 22.6 gm in weight, into eight groups of 100 mice each for mortality studies.

Aluminum chambers 2 x 3 x 2 feet with plexiglass windows were constructed for exposing these animals to aerosols . . . [Full Text PDF of this Article]

Author Affiliations
Miami, Fla

From the Department of Anesthesiology, University of Miami School of Medicine and Jackson Memorial Hospital, Miami, Fla.

Footnotes
Received for publication April 18, 1967.

Reprint requests to PO Box 875, Biscayne Annex, Miami Fla 33152 (Dr. Modell).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?