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Joseph A. Bellanti, MD

Am J Dis Child. 1968;115(2):239-246.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

OVER THE PAST several years, work in our laboratory has focused on studies of the occurrence and characterization of specific antibodies in secretions of the respiratory tract in an attempt to identify their biological significance in immunity.^1-7 These studies arose from the need for a simple biological marker of immunity which could identify individuals most likely to resist overt respiratory tract infection with any of a number of pathogens, particularly viruses. The results of these studies suggest that antibody in respiratory secretions is predominantly of the A-immunoglobulin variety and the presence of such antibody appears to correlate better with resistance to infection than humoral antibody.^2,3,6,7

In a series of extremely important experiments, Tomasi et al,⁸ Chodirker and Tomasi,⁹ and Tomasi and Zigelbaum¹⁰ demonstrated that the particular type of A-immunoglobulins in external secretions which bathe organs and systems in continuity with the external environment, was of . . . [Full Text PDF of this Article]

Author Affiliations
Washington, DC

From the departments of pediatrics and microbiology, Georgetown University School of Medicine, Washington, DC.

Footnotes
Received for publication Oct 19, 1967.

Submitted by the author for the Mitchell I. Rubin Festschrift issue of the JOURNAL.

Reprint requests to 3800 Reservoir Rd, Washington, DC 20007 (Dr. Bellanti).

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