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Donald Pinkel, MD

Am J Dis Child. 1968;115(2):222-238.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

RECENT STUDIES have demonstrated that the thymus is essential in newborn rodents for development of immunological competence¹ and for induction of lymphatic leukemia.² The ultrastructure of normal mouse thymus has been studied by Clark³ and by Weiss⁴ and the ultrastructure of fetal hamster thymus by Weakley et al.⁵ Others have examined thymus of mice with virusinduced leukemia⁶ and have reported numerous virus particles at the surfaces of lymphocytes, in the intercellular spaces, and in phagocytes. However, De-Harven⁷ has described virus-like particles in thymus of normal Swiss mice.

In conjunction with electron microscopic studies of human leukemic thymus, the thymus glands of 20 human fetuses were examined to provide information concerning their ultrastructure and to determine whether virus-like particles could be identified.

Materials and Methods

Thymus glands were obtained at postmortem examination from 20 liveborn human fetuses resulting from spontaneous abortions or premature . . . [Full Text PDF of this Article]

Author Affiliations
Memphis

From the Laboratory of Virology, St. Jude Children's Research Hospital and the Department of Pediatrics, University of Tennessee, Memphis.

Footnotes
Received for publication Sept 18, 1967.

Read before the Tenth International Congress of Hematology, Stockholm, September 1964.

Submitted by the author for the Mitchell I. Rubin Festschrift issue of the JOURNAL.

Reprint requests to 332 N Lauderdale, PO Box 318, Memphis 38101 (Dr. Pinkel).

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