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Arno R. Hohn, MD; Jon B. Tingelstad, MD; Raquel Israel, MD; Iain F. S. Black, MD; Edward C. Lambert, MD

Am J Dis Child. 1968;115(2):202-206.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN THE ABSENCE of pulmonary disease, reduced systemic arterial oxygen saturation is usually accepted as evidence of a right-to-left intracardiac shunt in patients with congenital heart disease. However, several authors^1-4 have reported reduced arterial oxygen saturations in both systemic arterial and pulmonary venous samples in some patients with large left-to-right shunts. They suggested that this was caused by rapid flow through dilated pulmonary channels, impaired diffusion resulting from a high pulmonary flow, or a bypass of the alveoli through precapillary shunts in such patients.

With one exception⁴ these workers employed methods which measured only oxygen content and saturation in assessing the right-to-left intrapulmonary shunts. Because of the conflicting opinions regarding such shunts investigated by relatively insensitive techniques, it was felt worthwhile to reevaluate them with modern polarographic measurements of oxygen tension.

Due to the shape of the blood oxygen dissociation curve, the current polarographic method of direct measurement . . . [Full Text PDF of this Article]

Author Affiliations
Buffalo

From the Department of Pediatrics, Children's Hospital, Buffalo (Dr. Lambert), The Medical College of South Carolina Hospital, Charleston, SC (Dr. Hohn), Medical College of Virginia, Richmond, Va (Dr. Tingelstad), and St. Christopher's Hospital for Children, Philadelphia (Dr. Black). Drs. Tingelstad, Israel, and Black were postdoctoral research fellows, National Institute of Child Health and Human Development, US Public Health Service.

Footnotes
Received for publication Oct 9, 1967.

Submitted by the authors for the Mitchell I. Rubin Festschrift issue of the JOURNAL.

Reprint requests to 219 Bryant St, Buffalo 14222 (Dr. Lambert).

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