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Kornel L. Terplan, MD; Maimon M. Cohen, PhD

Am J Dis Child. 1968;115(2):179-184.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SEVERAL RECENT publications describe distinct structural anomalies in various parts of the cerebellum, including the white matter, roof nuclei, and the dentates, in the trisomy 13-15 syndrome.^1-4 A striking duplicity of observations resulted from the simultaneous investigation of five cases in the Burden Neuropathological Laboratory of the Frenchay Hospital in Bristol³ and five cases in the Brain Laboratory of the Children's Hospital in Buffalo.⁴ Since similar changes, including in particular large accumulations of external granular layer cells in the white matter and in the dentate nuclei, have not been seen thus far in the cerebellum of infants with the trisomy 18 syndrome (examined in a nearly equal number of cases, four in one laboratory³ and five in the other⁴), the need for detailed study of the central nervous system (CNS), and of the cerebellum in particular, in all cases of trisomy is emphasized.^3,4 Only . . . [Full Text PDF of this Article]

Author Affiliations
Buffalo

From the Brain Laboratory (Dr. Terplan) and the Division of Human Genetics (Dr. Cohen) Department of Pediatrics, Children's Hospital of Buffalo (Drs. Terplan and Cohen), and the State University of New York at Buffalo, Medical School, Buffalo.

Footnotes
Received for publication Aug 30, 1967.

Submitted by the authors for the Mitchell I. Rubin Festschrift issue of the JOURNAL.

Reprint requests to 219 Bryant St, Buffalo 14222 (Dr. Terplan).

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