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Richard M. Rothberg, MD; Lt Cdr Robert W. ten Bensel, MC

Am J Dis Child. 1967;113(6):639-648.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE DEMONSTRATION that immunoglobulin production was normal or minimally impaired in neonatally thymectomized animals^1-3 has led to the speculation that man may have two distinct types of peripheral lymphoid tissue, each dependent upon a different primordial gut-associated lymphoid tissue ("central lymphoid tissue") for its development.⁴ The peripheral lymphoid tissue considered dependent on the thymus as the central lymphoid tissue ("thymic-dependent tissue") is the small lymphocyte which has an important role in delayed hypersensitivity and homograft rejection.^3,5,6 The other peripheral lymphoid tissue consists of the large pyroninophilic lymphocytes and plasma cells which produce the immunoglobulins⁷ and is referred to as the immunoglobulin-producing system. The central lymphoid tissue of the immunoglobulin-producing system, has been definitely identified only in the chicken where the bursa of Fabricius, a hindgut lymphoid organ, is this central lymphoid tissue.^3,8

These considerations have led to the suggestion that some of the immune-deficiency diseases . . . [Full Text PDF of this Article]

Author Affiliations
USNR, San Diego, Calif

From the Division of Allergy, Immunology, and Rheumatology, Scripps Clinic and Research Foundation (Dr. Rothberg), the US Naval Hospital, San Diego (Dr. ten Bensel) and the Department of Pediatrics, Mercy Hospital, San Diego, Calif.

Footnotes
Received for publication Sept 6, 1966.

The opinions and assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Navy Department or the Naval Service at large.

Reprint requests to Department of Pediatrics, University of Chicago School of Medicine, 950 E 59th St, Chicago 60637 (Dr. Rothberg).

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