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Neonatal Manifestations of Hereditary Spherocytosis
Jaime I. Trucco, MD;
Audrey K. Brown, MD
Am J Dis Child. 1967;113(2):263-270.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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THOUGH the natural history of hereditary spherocytosis in adults has long been recognized,1 only recently have investigators become interested in the expression of this inborn error of red-cell metabolism in the neonate.2-9 Although almost 50% of all adults with this disease give a history of significant jaundice in the newborn period,5 the majority of cases are not diagnosed until much later. Overt hemolysis, hyperbilirubinemia and even kernicterus, have been recognized in the newborn with this defect,10,11 and it is now evident that if nurseries seek the cause of exaggerated jaundice, the discovery of this hereditary red-cell defect among infants with hyperbilirubinemia is surprisingly frequent. In our experience, a significant number of full-term infants with hyperbilirubinemia without iso-immunization are found to have hereditary spherocytosis. While hereditary spherocytosis is most common in whites, Negro infants have been diagnosed in the newborn period.4
This report reviews the natural
. . . [Full Text PDF of this Article]
Author Affiliations
Charlottesville, Va
From the Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Va. Dr. Brown is now at the Medical College of Georgia, Augusta, Ga. Dr. Trucco is a fellow in Pediatric Hematology, Child Research Center of Michigan, Detroit.
Footnotes
Received for publication June 29, 1966.
Reprint requests to Medical College of Georgia, Augusta, Ga 30902 (Dr. Brown).
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