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Search for Such Phenomena in Cancers of Children

ALBERT B. SABIN, MD

Am J Dis Child. 1966;111(1):1-10.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

BEFORE ANIMAL cells were experimentally converted to malignancy by certain viruses, there was no evidence of continuous transmission of noninfectious, viral genetic material in them. The recognized manifestations of viral infection in animal cells were associated with synthesis of infectious virus which led either to destruction of the infected cells or to the cellular proliferation seen in the benign papillomas of viral etiology. The few, naturally-occurring, malignant tumors of established viral etiology are caused by viruses (apparently all of the ribonucleic acid [RNA] type) which can replicate to the fully infectious state in the tumor cells.

Another type of association between viruses and cells of special significance now for investigations on mammalian tumor cells emerged from the illuminating studies on bacterial viruses which revealed the phenomenon of lysogeny—a phenomenon in which a portion of the viral genetic material, called provirus, is integrated with the genetic material of the host and . . . [Full Text PDF of this Article]

Author Affiliations
CINCINNATI

From the Children's Hospital Research Foundation, Universitycinnati College of Medicine, Cincinnati.

Footnotes
Received for publication Aug 26, 1965.

Read before the Group Panel Discussion on "Microbial Genetics in Relation to Pediatrics" at the 11th International Congress of Pediatrics, Tokyo, Nov 10, 1965.

Reprint requests to Children's Hospital Research l Research Founda-ethesda,llanncinnati, Ohio 45229.

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