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Studies of Breath Excretion of C14O2 After Ingestion of Labeled Fatty Acids, Glucose, and Lactose

FRANK J. COZZETTO, MD

Am J Dis Child. 1964;107(6):605-611.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The breath excretion of radiocarbon is an important quantitative measurement of the catabolic fate of carbon, and the excretion of labeled carbon dioxide from carbon 14-tagged metabolites potentially is a dynamic way of studying metabolic functions in living organisms.¹ Breath excretion of carbon 14 dioxide represents a nondestructive method of investigating intermediary metabolism in patients, and if the rates of C¹⁴O₂ respiration are measured from a variety of labeled substrates, it should be possible to define the relative importance of major metabolic patterns. In a given patient it is possible to obtain information on a specific metabolic process with the intravenous administration of a selected substrate.^2-6

Our interest in this technique has been directed to the study of absorption from the gastrointestinal tract after the ingestion of labeled substrates. Because of the relative inaccessibility of the intestinal tract and because of the difficulties encountered when . . . [Full Text PDF of this Article]

Author Affiliations
DENVER

Frank J. Cozzetto, MD, Department of Pediatrics, University of Colorado Medical Center, 4200 E Ninth Ave, Denver, Colo 80220.; Assistant Professor, Department of Pediatrics, University of Colorado Medical Center.

Footnotes
Received for publication Oct 22, 1963.

This study was supported by Grants-in-Aid from the National Cystic Fibrosis Research Foundation and from United States Public Health Service No. AM 05693-02, No. FR-69, and No. MSRT-2R-62.

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