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Response to Cooling

D. A. FISHER, MD; T. H. ODDIE, DSc

Am J Dis Child. 1964;107(6):574-581.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

During the first few days of postnatal life, serum hormonal iodine values ^1-3 and triiodothyronine I 131 erythrocyte uptake ^4,5 have been shown to increase significantly. In a previous report we have shown that these increases occur in association with an early (10-24 hours of age) high rate of thyroid I¹³¹ clearance ⁶ which suggests that this neonatal thyroidal hyperactivity may be the result of stimulation by thyroid stimulating hormone (TSH) during the early hours of postnatal life.

The present studies report further investigations of thyroid radioiodine uptake and studies of the influence of neonatal cooling and exogenous adrenal cortical steroid on neonatal thyroidal hyperactivity.

Methods

Protein-bound iodine (PBI) determinations were conducted at Bioscience Laboratories by Barker's alkaline ashing technique. Fractional thyroid radioiodine clearance measurements (k₁)* and 24-hour thyroid I¹³¹ uptake were conducted by methods previously reported.⁶ Radioiodine doses of 1µC were employed in the . . . [Full Text PDF of this Article]

Author Affiliations
LITTLE ROCK, ARK

D. A. Fisher, MD, University of Arkansas Medical Center, Little Rock, Ark 72201.; Associate Professor of Pediatrics (Dr. Fisher) and Associate Professor of Radiology, University of Arkansas Medical School (Dr. Oddie).; From the departments of Pediatrics and Radiology, University of Arkansas Medical School.

Footnotes
Received for publication Dec 3, 1963.

These investigations were supported by Public Health Service grants No. AM-04822 and AM-05438 of the National Institute of Arthritis and Metabolic Disease.

k1 Indicates fractional rate of removal (per minute) of radioiodide from the radioiodide space by the thyroid gland over the period 0-30 minutes after injection. Over this period the thyroid gland clears an average amount of 100 k1% of the radioiodide pool each minute. Details of measurement and computation of k, have been published.6-9

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