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HILARY KOPROWSKI, M.D.

Am J Dis Child. 1962;103(3):273-278.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This concept of hyperergy in measles was presented by von Pirquet almost half a century ago.1 This great clinician, who coined the term "allergy," was audacious enough to formulate as an explanation of the signs and symptoms of measles a theory which remains very much au courant today. Direct experimental evidence supporting this hypothesis is still as scarce at present as it was in the time of von Pirquet, but indirect evidence accumulated during the past 20 years suggests that a "nonspecific" reaction of the host to a virus infection is perhaps one of the few factors which among many others 2 of less importance may decide the ultimate outcome of the infection. Although we have little knowledge of the mechanisms operative in a virus disease of mammalian species, a hypersensitive reaction of the host to the multiplying virus, or to the products of damage inflicted by the virus on . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

Dr. Hilary Koprowski, Director, The Wistar Institute, Philadelphia 4.

Footnotes
Presented at the International Conference on Measles Immunization, National Institutes of Health, Bethesda, Md., Nov. 7-9, 1961.

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