 |
|
Antibiotic Toxicity in Newborn and Adult RatsA Potentially Useful Drug Screening Procedure
ALFRED F. MICHAEL, M.D.;
JAMES M. SUTHERLAND, M.D.
Am J Dis Child. 1961;101(4):442-446.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
The occurrence of chloramphenicol toxicity in the newborn and premature infant is a well-documented clinical entity that occurs if a critical dose or blood level is exceeded.1-6 The cardiovascular collapse and death are associated with elevated levels of chloramphenicol, which are the result of immature renal excretory functions and also of the immature hepatic conjugating mechanism. These mechanisms are well developed in the older child and adult and hence this type of toxicity has not been described in patients receiving usual therapeutic doses of chloramphenicol. In patients with hepatic cirrhosis and severe renal disease, however, there is retention of chloramphenicol and its metabolic product.7
The evaluation of any experimental drug prior to clinical use requires animal toxicity studies. The effect on the newborn animal is not routinely appraised however. The finding that chloramphenicol is 14 times more toxic to the newborn than the adult rat8 and the
. . . [Full Text PDF of this Article]
Author Affiliations
CINCINNATI
From the Department of Obstetrics and the Department of Pediatrics, University of Cincinnati College of Medicine; the Laboratory for the Study of Infant and Maternal Health, and the Children's Hospital Research Foundation.
Footnotes
Submitted for publication Oct. 11, 1960.
Children's Hospital Research Foundation, Elland Ave. and Bethesda.
Supported by Grant RG-5099, U.S. Public Health Service, The Department of Health, Education, and Welfare.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
