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II. Factors Which Alter Bilirubin Concentration and Frequency of Kernicterus

LOIS JOHNSON, M.D.; MARIA LUISA GARCIA, M.D.; ESPERANZA FIGUEROA, M.D.; FELICITAS SARMIENTO, M.D.

Am J Dis Child. 1961;101(3):322-349.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In previous papers,^20,5,55 we have described the occurrence of kernicterus in the Gunn strain of rats, as well as some of the factors which influence its incidence and pathogenesis. This paper concludes our current study of the rats and summarizes approximately 2 years of observation.

Methods and Terminology

As in the previous papers, the jaundice gene is designated by the small letter j and the normal gene by the capital letter J.⁵⁵

Kernicterus is defined as previously⁵⁵ and is abbreviated in tables as KI.

The methods for serum bilirubin (S.B.) and sulfonamide determinations have been previously described.⁵⁵ Sodium p-aminohippurate (Na PAH) determinations were done by a micromodification of the method of Smith.⁹⁴ Sodium glucuronate (Na GA) was determined by a micromodification of the method of Fishman.²⁹ Total protein (T.P.) determinations were done on 20 of serum by an unpublished modification of the biuret . . . [Full Text PDF of this Article]

Author Affiliations
BROOKLYN

From the Department of Pediatrics of the State University of New York, Downstate Medical Center.

Footnotes
Submitted for publication Aug. 18, 1960.

Supported by Grant No. B661 (C4) of the U.S. Public Health Service.

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