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How to Fight Whooping Cough?
Florens G. A. Versteegh, MD, PhD;
Kathryn M. Edwards, MD
Arch Pediatr Adolesc Med. Published online January 2, 2012. doi:10.1001/archpediatrics.2011.1243
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The large whooping cough outbreak experienced in California in 2010 highlights that Bordetella pertussis is still a real threat.1 Moreover, increases in disease are not only seen in the United States but worldwide.2-4 Since pertussis is a highly contagious respiratory tract infection associated with high mortality rates in infants, new vaccination approaches are being evaluated to assess their impact on B pertussis burden.5-7
With the introduction and widespread use of combined diphtheria and tetanus toxoids and whole-cell pertussis vaccine (DTP) in the 1940s in the United States and in the early 1950s in the Netherlands, the incidence of pertussis markedly declined, with the lowest reported rates in the United States during the early 1980s.8 However, great concern over common local and systemic reactions after DTP led to vaccine refusal and the development of new more highly purified vaccines. These "acellular . . . [Full Text of this Article] AUTHOR INFORMATION
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