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Autism
A Review of the State of the Science for Pediatric Primary Health Care Clinicians
William J. Barbaresi, MD;
Slavica K. Katusic, MD;
Robert G. Voigt, MD
Arch Pediatr Adolesc Med. 2006;160:1167-1175.
ABSTRACT
Autism is a complex neurodevelopmental disorder characterized by impaired reciprocal social interaction, impaired communication, and restricted, repetitive, or stereotyped behaviors. Autism seems to affect more children than was previously believed, although this phenomenon may be due to broadening of the diagnostic criteria and increased awareness of the condition. Recent research has clearly indicated the importance of early identification, since early intensive treatment is associated with better long-term outcome. There are many controversies and competing theories about the etiology and treatment of autism, often leaving families confused about the best course of treatment and intervention. Pediatric primary health care clinicians have an important role in both the early identification and ongoing management of children with autism. It is, therefore, essential that primary care clinicians have up-to-date information about the science of autism.
WHY A REVIEW ON AUTISM?
Autism and related conditions in the autism spectrum have become the focus of intense interest fueled by concerns about the apparent increase in the number of children with these developmental disorders.1-2 Pediatricians have an important role in the identification and ongoing management of children with autism. This article provides pediatric clinicians with a contemporary understanding of autism, including definitions, epidemiology, initial identification, formal diagnostic approaches, medical evaluation, treatment, controversies, and caregiver support.
WHAT IS AUTISM?
Autism, first described in 1943, is a complex developmental disorder characterized by severe impairment in reciprocal social interaction and communication and by a pattern of repetitive or stereotyped behavior.3-4 The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV, TR) includes autistic disorder in the broader category of pervasive developmental disorders, along with pervasive developmental disorder, not otherwise specified (PDD-NOS), Asperger's disorder, Rett's disorder, and childhood disintegrative disorder.3 Autistic disorder, PDD-NOS, and Asperger's disorder are often collectively referred to as the autism spectrum disorders (ASDs), while the term autism is used interchangeably with the DSM-IV, TR term autistic disorder. The term ASDs reflects the notion that these conditions are related and may be difficult to differentiate with current diagnostic tools.5-8 Pervasive developmental disorder, not otherwise specified is a somewhat ill-defined diagnosis of exclusion reserved for children with problems similar to those seen in autistic disorder but insufficient to meet the criteria for autistic disorder in number, severity, or age at onset.3, 6-7
The diagnostic criteria for autism require the presence of 6 symptoms from 3 categories: impaired reciprocal social interaction (at least 2 symptoms), impaired communication, and restricted, repetitive, or stereotyped behaviors (Table 1). These criteria reflect the central role of deficits in social behavior in children with ASDs.3, 9-10 One of the earliest and most important indicators of autism is the failure to develop joint attention,7, 11-12 which refers to the child's ability to share interests, pleasurable experiences, or requests by using gestures or verbal communication in combination with eye contact with another person.
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Table 1. Diagnostic Criteria for Autistic Disorder*
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EPIDEMIOLOGY
There is widespread public concern about the apparent increase in autism, based on prevalence studies during the last 20 years.1, 13-17 Studies from the 1980s and early 1990s reported a prevalence of 4 to 10 per 10 000 children, whereas recent studies have reported prevalences of 30 to 50 per 10 000 children.1, 13-18 Studies that rely on administrative data for children who receive special education services have reported significant increases in prevalence from 1992 to 2001.19 A recent study in a single US county demonstrated an apparent increase in the incidence of research-identified autism among individuals 21 years of age or younger, from 5.5 per 100 000 in the 1980-1983 period to 44.9 per 100 000 in the 1995-1997 period.1 The advantage this incidence study had over previous prevalence studies was in its reporting rates of newly identified cases in the same community over many years with the use of consistent DSM-IV, TR–based research criteria for case identification. The timing of this apparent increase coincided with the introduction of broader diagnostic criteria, increased availability of educational services, and increased awareness of autism. These findings were not consistent with the hypotheses that immunization policy or the vaccine preservative thimerosal have contributed to this epidemiologic phenomenon.1, 20 A recent review also noted the absence of published literature that demonstrates increased rates of autism in children who have been immunized with vaccines containing thimerosal.20 A study from the United Kingdom also concluded that the observed increase in the rate of diagnosis of pervasive developmental disorder is likely the result of better case ascertainment rather than a true increase in autism.21
IDENTIFICATION OF AUTISM BY PEDIATRIC PRIMARY HEALTH CARE CLINICIANS
Early identification of autism is important because early intervention services may be more effective in children with autism than in children with other developmental disabilities.22 Pediatric clinicians are ideally positioned to assume this role, aided by practice guidelines for the diagnosis and management of ASDs in children.7, 23-24 A 2-level approach to autism screening and diagnosis is recommended.7 In children who fail routine developmental screening, specific screening for autism should be performed25-28 (Table 2). In children who fail specific autism screening, referral for a formal evaluation by an experienced clinician is recommended. Referral is also recommended for any child who does not babble or point or use other gestures by the age of 12 months, who uses no single words by 16 months or no spontaneous (nonecholalic) 2-word phrases by 24 months, or who experiences any loss of any language or social skills at any age.7
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Table 2. Autism-Specific Screening Tools
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Deficits in joint attention differentiate infants with autism from those with mental retardation or typical development.29-32 These behaviors include deficits in the following areas: eye contact, orientation to name being called, pointing, and showing. In the toddler age group, a lack of pretend play and imitation, deficits in nonverbal communication, and disproportionate language delays differentiate autism from other developmental disorders.7 Although repetitive behaviors, stereotypic motor mannerisms, atypical sensory responses, and behavioral outbursts are generally observed in children with autism, these behaviors do not consistently differentiate autism from other developmental disorders at early ages.7
The Modified Checklist for Autism in Toddlers (M-CHAT) has been developed as an autism-specific screening tool for use in 24-month-old children (Table 2).33-36 It consists of 23 items based on parental report, which makes this checklist efficient for use in primary care settings. Other promising screening instruments include the Pervasive Developmental Disorders Screening Test–II37 and the Screening Tool for Autism in Two-Year Olds.38 For children who are 4 years or older, the Social Communication Questionnaire may be used as an autism screening instrument.7, 27-28
Children with autism can also be identified by a characteristic early developmental profile, with relative strengths in visuomotor problem solving and discrepant and disproportionate weaknesses in language.39-50 The Cognitive Adaptive Test/Clinical Linguistic and Auditory Milestone Scale (Capute Scales) provides quantitative information about a child's development in the domains of language and visuomotor problem solving and can be used efficiently for this purpose in primary care settings.51
DIAGNOSING AUTISM
A comprehensive, multidisciplinary assessment is required to evaluate a child for an ASD and to differentiate ASDs from other developmental disorders.5-7,12, 52 Since there are no definitive diagnostic tests, a clinical diagnosis by an expert, based on DSM-IV, TR criteria, remains the gold standard of ASD diagnosis.6-7,12, 52 The DSM-IV, TR criteria consist of a list of behaviors that are not described in detail, leaving considerable latitude for clinical judgment.3, 7, 12 Children who have been evaluated exclusively by school or early intervention staff should not be considered to have undergone a thorough diagnostic assessment. This can be confusing to both parents and pediatricians, given the existence of the explicit special education category "Autism Spectrum Disorders" (Individuals with Disabilities Education Act [IDEA] 97, Pub L No. 105-17).53 An ASD designation for special education purposes may be obtained without a clinical diagnosis of an ASD. Furthermore, children with autism or PDD-NOS often have severe cognitive, communicative, and behavioral problems that can only be assessed by a team of professionals (Table 3). The clinical diagnosis of an ASD is facilitated by the use of rating scales and direct assessment tools specifically developed for this purpose (Table 4).54-59
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Table 3. Professionals Who May Be Included in Multidisciplinary Assessment for Autism
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Table 4. Autism-Specific Diagnostic Tools
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Approximately 60% to 75% of children with autistic disorder or PDD-NOS have cognitive skills in the mentally retarded range (standard scores <70 on formal cognitive tests).1, 3 Fewer children with PDD-NOS are likely to function in the mentally retarded range.52 Children with autism or PDD-NOS often demonstrate relative strength in visual problem-solving skills and relative weakness in language-based cognitive skills; this discrepant cognitive profile may be reflected in a significant discrepancy between verbal and performance IQ scores.3, 7, 39-50,52 Formal cognitive assessment should be completed using instruments that have been demonstrated to be appropriate60-67 (Table 5).
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Table 5. Cognitive Assessment Tools
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Similarly, formal speech and language assessment is essential because communication deficits of varying severity are always present in children with ASD.3, 7, 12 Children with ASD may have specific deficits in the social use of language, often referred to as pragmatic language.3, 7, 12 For example, a child may be able to recite long segments of dialogue from a favorite video yet not be able to use a 3-word sentence to ask for something to eat. Problems with pragmatic language are often identified only by a careful history or direct observation of the child in his or her natural environment.3, 7, 12
Social-adaptive behavioral assessments should include assessment of functional skills such as sleeping, eating, and toileting and problem behaviors such as aggression, oppositionality, and self-injury. This assessment is facilitated by the use of formal questionnaires and rating scales including, among others, the Vineland Adaptive Behavior Scales and the Scales of Independent Behavior.68-69 Formal assessments of fine and gross motor skills may be incorporated into the evaluation as indicated. Parent resources should be carefully assessed to enable the team to understand the context of the child's developmental problems and to ensure that plans are made to provide appropriate support to the family.
MEDICAL EVALUATION OF CHILDREN WITH AUTISM
Every child with autism should undergo a formal audiologic evaluation, whether or not the child passed a newborn hearing screening test. In addition, children with autism are at risk of lead toxicity, given their high prevalence of putting objects in their mouths.70 Thus, periodic lead screening should be performed until pica resolves.7
Although a recognizable etiologic disorder is found in fewer than 25% of individuals with autism, attempts to establish an etiologic diagnosis to account for this clinical syndrome are important to identify diagnoses that may affect prognosis, risk of recurrence, and associated medical morbidity. A thorough history and physical examination should guide the medical diagnostic workup71-77 (Table 6). Since tuberous sclerosis accounts for up to 3% to 4% of autism cases, Wood's lamp examinations should be performed in every child with autism to detect the hypopigmented macules associated with this syndrome, especially if the child has an intercurrent seizure disorder.78 While routine head imaging (computed tomography or magnetic resonance imaging) is not recommended, recent studies have reported abnormal patterns of brain growth in individuals with autism.79 Functional imaging techniques are currently used as research tools but are not indicated in routine clinical practice.7, 80-81
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Table 6. Medical and Genetic Evaluation of Children With Autism
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Autism has been associated with many genetic syndromes, including Down syndrome, Angelman syndrome, de Lange syndrome, Smith-Magenis syndrome, and Smith-Lemli-Opitz syndrome.82-83 Seven percent to 8% of individuals with autism have fragile X syndrome.84 In addition, anomalies in almost every chromosome have been reported in individuals with autism, although more consistent linkage findings have been associated with chromosomes 2q, 7q, and 15q.85 Thus, DNA testing for fragile X syndrome and high-resolution chromosome analyses are recommended in the laboratory workup in children with autism, especially those with mental retardation, dysmorphic features, congenital anomalies, or a family history of autism or mental retardation.7, 84 Fluorescent in situ hybridization testing for specific chromosome deletions, duplications, or inversions should be considered if initial investigations produce negative results84-87 (Table 6). Even in the absence of a specific genetic diagnosis, the recurrence rate in siblings of children with autism is between 2% and 8%, increasing the risk of having a second child with autism nearly 50-fold over that in the general population.84
Although a wide range of inborn errors of metabolism have been associated with autistic behavior, less than 5% of children with autism have identifiable metabolic disorders.88-93 Thus, metabolic testing is particularly indicated when the autistic behaviors are accompanied by a history of developmental plateauing or regression; decompensation with mild illness, unusual odors, or food intolerance; failure to thrive; episodic lethargy; cyclic vomiting; seizures; coarse features; mental retardation; questionable newborn screening results; or birth outside the United States7 (Table 6).
By adulthood, about one third of individuals with autism will have at least 2 unprovoked epileptic seizures.82 Onset of seizures in individuals with autism follows a bimodal age distribution, with peaks in early childhood and adolescence.7, 94 All seizure types, including infantile spasms, can be associated with autism, but partial complex seizures, with electroencephalographic abnormalities occurring most often over the temporal lobes, appear to be most prevalent.95 About one third of parents of children with autism report regression of language in their children, most commonly the loss of their toddler's first few words, between age 18 and 24 months.94, 96 Approximately 10% of children with autism also have a paroxysmal electroencephalographic pattern similar to that seen in Landau-Kleffner syndrome (acquired epileptic aphasia) or electrical status epilepticus during slow-wave sleep.94 While there have been reports of the use of anticonvulsant therapy and even epilepsy surgery, there is insufficient evidence to recommend routine electroencephalography in all children with autism.97-99 Indications for prolonged sleep-deprived electroencephalography with adequate sampling of slow-wave sleep are listed in Table 6.7
EDUCATIONAL AND BEHAVIORAL INTERVENTIONS
Pediatricians have an important role in helping to guide families toward intervention approaches that have been empirically demonstrated as effective.5, 52, 100 In the Internet era, families have access to virtually limitless information about treatments and interventions for autism. Since family resources of time, energy, and finances are limited, it is essential to ensure that these resources are directed toward interventions that offer the best hope for improved outcome.
The Individuals with Disabilities Education Act mandates educational services for children in the special education category of Autism Spectrum Disorders.52 The provisions of the Individuals with Disabilities Education Act do not, however, ensure that children will receive empirically validated interventions of appropriate intensity. There is, therefore, considerable variability in the quality of educational interventions for children with ASD. This is an additional important reason for pediatricians to understand and advocate for optimal services.
Decades-worth of scientific research provide clear and convincing support for the technique referred to as Applied Behavior Analysis (ABA).5, 100 This technique uses the principles of operant conditioning to teach specific social, communicative, and behavioral skills to children with ASD.5, 100 It involves teaching new behaviors by explicit reinforcement of these behaviors; problem behaviors are often addressed by carefully analyzing triggers or antecedents of the problem behavior in order to change the factors in the environment that are contributing to the problem behavior. Applied Behavior Analysis also uses careful collection of data to demonstrate the efficacy of treatment in the individual child; the data are used to assess progress and to continually modify the intervention as the child progresses toward specific learning objectives.101
Interest in ABA as a primary, comprehensive treatment approach in children with ASD was sparked by the research of Lovaas,102-103 who reported that 9 (47%) of 19 young children with autism who received intensive, early ABA (40 hours per week for  2 years) had outcomes that were indistinguishable from their normally developing peers.103 Subsequent studies have led many experts in the field to conclude that intensive ABA is an effective intervention but that it is unlikely that 50% of children who receive early, intensive ABA will achieve completely normal developmental outcomes.100, 104-107 Practice guidelines have used these and other research findings to formulate recommendations on the key features of appropriate intervention for children with autism.5, 52, 100 Characteristics of effective intervention are believed to include a minimum of 20 hours per week of carefully organized services initiated at an early age (preferably younger than 4 years) and involving direct adult attention in individual or very small group instruction.5, 7, 52, 100 Recent studies have concluded that intensity of intervention is important (ie, a minimum of 20 hours per week) and that ABA is superior to other intervention strategies.100, 108
Another intervention model with a long history and well-defined instructional methods is TEACCH (Treatment and Education of Autistic and Related Communication Handicapped Children).109 The TEACCH approach takes advantage of relative strengths in visual information processing, characteristic of many children with ASD, using strategies such as visual schedules, clearly structured and organized classrooms, and highly structured learning activities that are broken down into manageable, visually organized steps. Published reports demonstrate improvement in behaviors and functional skills and parent satisfaction with the TEACCH approach.52, 109-110 However, there appear to be no direct studies of treatment outcomes attributable to TEACCH interventions.
While other intervention strategies are often recommended, there do not appear to be approaches that have the empirical support of ABA or the long history and well-developed curricula of TEACCH. The weight of currently available scientific evidence, however, indicates that ABA should be viewed as the optimal, comprehensive treatment approach in young children with ASD.
Pediatricians should also be aware of sensory integration therapy because this approach is often used in special education programs. Interest in sensory integration is related to the observation that children with ASD often exhibit unusual sensory responses, such as hypersensitivity to certain noises. Techniques used in this therapy include "brushing" of the skin, "swinging" to stimulate vestibular responses, and deep-pressure massage applied in an effort to calm the child.52 There is no available empirical support for sensory integration therapy, and it should, therefore, neither be routinely recommended nor viewed as a primary intervention strategy in children with ASD.5, 52
Many other unproved nonmedical therapies have been recommended for use in children with autism. There is no evidence to support the use of facilitated communication, auditory integration training, or music therapy.5, 111-115
MEDICAL INTERVENTIONS FOR CHILDREN WITH AUTISM
Although psychopharmacologic therapies have been studied for more than 50 years, there are no Food and Drug Administration–approved indications for the treatment of autism with any agent and there is no medication available for treatment of the core deficits in communication and social interaction.116 In addition, when used to treat similar target behaviors, psychotropic medications tend to be less effective and result in more adverse effects when used in children with autism compared with children without autism because of similar target behavioral symptoms. However, there is an evidence base for prescribing risperidone to assist in managing tantrums, aggression, and self-injurious and stereotypic behaviors and for prescribing methylphenidate to manage inattentive, impulsive, and hyperactive behaviors in children with autism.117-118 To date, there is insufficient evidence to support the use of selective serotonin reuptake inhibitors,  2-adrenergic agonists, or mood stabilizers, despite reports of their effectiveness in managing target behavioral symptoms in some children with autism in short-term open-label trials with small sample sizes.119-121 Psychotropic medications should never be used in isolation but used only in conjunction with behavioral, educational, and habilitative therapies.122 If psychotropic medications are used, initial dosage should be low, with gradual increases in dosage until optimal positive effects, without significant adverse effects, are achieved.
UNPROVED THEORIES OF CAUSATION AND UNPROVED OR INEFFECTIVE TREATMENTS IN CHILDREN WITH AUTISM
Traditional medicine does not offer a cure for autism. As a result, unproved complementary and alternative treatments are often provided to children with autism by parents who are seeking effective biomedical interventions.123 Patients with chronic conditions with unclear pathophysiologic features, fluctuating courses, highly subjective symptoms, and few effective evidence-based treatments are most vulnerable to the placebo effect.< |
