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Picture of the Month—Diagnosis
Arch Pediatr Adolesc Med. 2009;163(5):482.
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Denouement and Comment: Neonatal Varicella Infection
The mother was diagnosed 2 days after delivery as having varicella. She did not have a prior history of varicella or documented immunization. The newborn received a varicella-zoster immunoglobulin preparation (VariZIG; Cangene Corporation, Winnipeg, Manitoba, Canada) on her third day of life just before discharge from the hospital. When the newborn returned for evaluation of the rash, varicella-zoster virus DNA was detected in the blood and the bloody cerebrospinal fluid by polymerase chain reaction. She was treated with intravenous acyclovir for 10 days.
Congenital varicella infections occur when pregnant mothers are infected during the first 2 trimesters of pregnancy. Clinical manifestations include cicatricial skin lesions in a dermatomal distribution, which are often depressed and pigmented. Neurologic defects, such as intellectual disability and seizures, may also occur. Ocular and skeletal defects are also present in half of cases.1 Neonatal varicella may be caused by maternal varicella infection during the last 3 . . . [Full Text of this Article]
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Arch Pediatr Adolesc Med. 2009;163(5):481.
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