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Ethics of Hematopoietic Stem Cell Donation by Biological Siblings of Adopted Children

Jennifer C. Kesselheim, MD, MBE; Leslie E. Lehmann, MD; Nancy Frumer Styron, PsyD, JD; Steven Joffe, MD, MPH

Arch Pediatr Adolesc Med. 2009;163(5):413-416.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Minor siblings routinely donate hematopoietic stem cells (HSC) for transplantation. However, the ethical justification for using minors as donors is controversial. Prompted by a recent case involving a biological sibling who, because of adoption, had no intimate relationship to the potential transplant recipient, we review systematically the ethical foundation for using minors as HSC donors. Analysis of the various potential justifications for using minor siblings as donors suggests that HSC donation in this case is ethically impermissible. Looking beyond this particular example, we contend that optimal patient advocacy requires that generalist and specialist pediatricians be familiar with the ethical framework that guides decisions about accepting minors as HSC donors.

A previously healthy 6-year-old boy who had been adopted as an infant was found to have acute lymphoblastic leukemia. Because initial cytogenetics revealed . . . [Full Text of this Article]

JUSTIFICATION FOR HSC DONATION BY MINORS

CONSEQUENTIALISM

INVOLUNTARY ALTRUISM

SUBSTITUTED JUDGMENT

BEST INTERESTS

INTRAFAMILIAL PRINCIPLE

INTIMATE ATTACHMENT

INTRAFAMILIAL OBLIGATIONS

BIOLOGICAL SIBLINGS OF ADOPTED CHILDREN AS HSC DONORS

CONCLUSIONS

AUTHOR INFORMATION


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RELATED LETTERS

The Ethics of Hematopoietic Stem Cell Donation by Minors
Lainie Friedman Ross
Arch Pediatr Adolesc Med. 2009;163(11):1065.
EXTRACT | FULL TEXT  

The Ethics of Hematopoietic Stem Cell Donation by Minors—Reply
Jennifer C. Kesselheim, Leslie E. Lehmann, Nancy Frumer Styron, and Steven Joffe
Arch Pediatr Adolesc Med. 2009;163(11):1065-1066.
EXTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The Ethics of Hematopoietic Stem Cell Donation by Minors
Ross
Arch Pediatr Adolesc Med 2009;163:1065-1065.
FULL TEXT  

The Ethics of Hematopoietic Stem Cell Donation by Minors--Reply
Kesselheim et al.
Arch Pediatr Adolesc Med 2009;163:1065-1066.
FULL TEXT