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Evaluation of a Study of Universal Primer Polymerase Chain Reaction for Identification of Neonatal Sepsis

Lisa Ross DeCamp, MD, MSPH; Amanda F. Dempsey, MD, PhD, MPH; Beth A. Tarini, MD, MS

Arch Pediatr Adolesc Med. 2009;163(1):12-14.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Differentiating bacterial sepsis from other conditions common in infants in the neonatal intensive care unit poses a number of challenges. First, clinical signs such as apnea, feeding intolerance, and need for increased respiratory support are nonspecific but still of concern for bacterial sepsis. These signs often prompt evaluation for sepsis that includes blood culture and antibiotic therapy for up to 48 hours while awaiting blood culture results. Second, blood culture accuracy may be decreased in neonates exposed to antibiotic agents during labor. Third, in some instances, a blood culture cannot be obtained before the initiation of antibiotic therapy. A test that could enable quick and accurate diagnosis of bacterial sepsis in these situations could avert unnecessary antibiotic therapy. To date, others tests such as white blood cell count, absolute neutrophil count, and C-reactive protein . . . [Full Text of this Article]

VALIDITY OF THE STUDY


DETERMINING THE TEST'S IMPORTANCE

APPLYING THE DIAGNOSTIC TEST TO OUR PATIENTS

CONCLUSIONS

AUTHOR INFORMATION


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