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Rachel C. Vreeman, MD, MS; S. Maria E. Finnell, MD; Erin R. Cernkovich, PhD; Aaron E. Carroll, MD, MS

Arch Pediatr Adolesc Med. 2008;162(9):866-869.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Acute gastroenteritis (GE) is a common childhood illness.^1-2 Although children with GE frequently have vomiting, current practice recommendations for pediatric GE do not include pharmacologic treatment for vomiting.¹ Furthermore, experimental studies of medications to treat pediatric GE-associated vomiting are limited. In this issue of the Archives, DeCamp et al³ performed a systematic review and meta-analysis to determine if antiemetic treatment reduces vomiting and decreases the need for further intervention in children with GE. Two assessment tools were used to determine the quality rating of each article. The primary outcome measures included cessation of emesis, use of intravenous fluid (IVF) for rehydration, hospital admission, return to care, and medication adverse effects.³

Using computerized databases, references lists, and expert recommendations, DeCamp et al identified 11 prospective controlled studies that met inclusion criteria. . . . [Full Text of this Article]

ARE THE RESULTS OF THIS SYSTEMATIC REVIEW VALID?

Is This a Systematic Review of Randomized Trials?

Does the Systematic Review Describe a Comprehensive and Detailed Search for Relevant Trials?

Were the Individual Studies Assessed for Validity?

Were Individual Patient Data Used in the Analysis?

ARE THE VALID RESULTS OF THIS SYSTEMATIC REVIEW OF THERAPY IMPORTANT?
Are the Results Consistent Across Studies?

What is the Magnitude of the Treatment Effect and How Precise Is It?

CAN WE APPLY THIS VALID, IMPORTANT EVIDENCE ABOUT THERAPY IN CARING FOR OUR PATIENT?
Is Our Patient so Different From Those in the Study That Its Result Cannot Apply?

Is the Treatment Feasible in Our Setting?

What Are Our Patient's Potential Benefits and Harms From the Therapy? Were All Clinically Important Outcomes Considered?

CONCLUSIONS

AUTHOR INFORMATION


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