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Peter Cummings, MD, MPH

Arch Pediatr Adolesc Med. 2008;162(8):734-737.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In this issue of Archives, Rozé and colleagues¹ report results from a cohort study of premature infants receiving mechanical ventilation after birth. Among infants treated with prolonged sedation or analgesia, 41 of 97 (42%) had later disability compared with 324 of 1248 (26%) other infants (crude [unadjusted] risk ratio, 1.6; 95% confidence interval, 1.3-2.1). The treated infants had characteristics that might cause disability, such as younger gestational age and more malformations at birth. Should the harmful association between treatment and disability be attributed to the treatment, the characteristics of those who received the treatment, both, or neither?

CONFOUNDING

When the causal effects of a treatment are entwined with other factors that may have causal effects, we call this confounding.^2-4 A clinical trial with random allocation to treatment can minimize confounding by measured and unmeasured factors, because random allocation will, on average, create treated and control groups . . . [Full Text of this Article]

PROPENSITY SCORES

OTHER USES OF PROPENSITY SCORES

CAUTIONS

CASE-CONTROL STUDIES

OUTCOME SCORES

CONCLUSIONS

AUTHOR INFORMATION


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Prolonged Sedation and/or Analgesia and 5-Year Neurodevelopment Outcome in Very Preterm Infants: Results From the EPIPAGE Cohort
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ABSTRACT | FULL TEXT