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Picture of the Month—Diagnosis
Arch Pediatr Adolesc Med. 2008;162(6):582.
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Denouement and Discussion: Chronic Bullous Dermatosis of Childhood
The physical finding of blisters arranged in the cluster of jewels pattern is highly suggestive of chronic bullous dermatosis of childhood (CBDC). With this presumed diagnosis, the patient's home medications were withheld and an empirical regimen of dapsone, 50 mg/d, and oral prednisone, 40 mg/d, was initiated. The patient was admitted for 48 hours for observation and wound care to denuded areas. Histopathologic examination of an intact vesicle demonstrated subepidermal cleft formation with a superficial perivascular, predominantly neutrophilic, infiltrate. Direct immunofluorescence performed on perilesional skin demonstrated linear staining along the basement membrane zone with IgA and C3, and minimally with IgG. These histopathologic findings confirmed the diagnosis of linear IgA bullous dermatosis/CBDC.
Chronic bullous dermatosis of childhood is an acquired autoimmune bullous disease of young children. It is the most common autoimmune bullous disease encountered within the pediatric population.1-2 The age at onset is reported to be between 6 months . . . [Full Text of this Article]
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Arch Pediatr Adolesc Med. 2008;162(6):581.
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Picture of the Month—Diagnosis
Arch Pediatr Adolesc Med. 2008;162(6):582.
EXTRACT
| FULL TEXT
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