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Arch Pediatr Adolesc Med. 2008;162(1):87.

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Denouement and Discussion: Vulvar Ulcerations Resulting From Acute Epstein-Barr Virus Infection

Recent reports have documented the role of Epstein-Barr virus (EBV) in causing vulvar ulcerations. With this in mind, serologic tests for EBV infection were performed in this patient. Results were negative for the Monospot test, EBV–viral capsid antigen IgM titer, and EBV–nuclear antigen IgG titer, but results were positive for the EBV–viral capsid antigen IgG titer at 166 (reference range, < 20), suggesting recent EBV infection. Based on these presenting clinical findings, we concluded that her vulvar ulcers were due to primary EBV infection. Two weeks later, her ulcers had healed completely and she had completely recovered from her illness.

Painful vulvar ulcerations (single or multiple) are, however, an uncommon but possibly underrecognized presentation of primary EBV infection in female adolescents. More than 25 cases of EBV-associated genital ulcers in females have been reported with a median age of 14.5 years.¹ Of the 26 cases, only 6 reported previous sexual contact.¹ . . . [Full Text of this Article]

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Arch Pediatr Adolesc Med. 2008;162(1):86.
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