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Making Progress for How Medicines Are Used in Children—Reply
Samir S. Shah, MD;
Matthew Hall, PhD;
Anthony D. Slonim, MD, DrPH
Arch Pediatr Adolesc Med. 2007;161(9):916-917.
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In reply
We thank Drs Taylor-Zapata and Mattison for their interest in our article. We also appreciate their clarification of the role of the National Institutes of Health and, more specifically, that of the National Institute of Child Health and Human Development in implementing the Best Pharmaceuticals for Children Act. We believe that these and other initiatives mentioned by the authors are critical to facilitate safe and effective prescribing for children.
In our study, off-label use of 90 drugs in patients from 31 geographically heterogeneous tertiary care children's hospitals accounted for more than $250 million.1 Almost 80% of children discharged from a participating hospital received at least 1 drug off-label. This high-level of off-label use likely underestimates the true magnitude of the problem, because we based our definition of off-label drug use solely on age criteria. Prescribing these . . . [Full Text of this Article] AUTHOR INFORMATION
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Arch Pediatr Adolesc Med. 2007;161(3):282-290.
ABSTRACT
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Making Progress for How Medicines Are Used in Children
Perdita Taylor-Zapata and Donald R. Mattison
Arch Pediatr Adolesc Med. 2007;161(9):916.
EXTRACT
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RELATED ARTICLE
Off-label Drug Use in Hospitalized Children
Samir S. Shah, Matthew Hall, Denise M. Goodman, Pamela Feuer, Vidya Sharma, Crayton Fargason, Jr, Daniel Hyman, Kathy Jenkins, Marjorie L. White, Fiona H. Levy, James E. Levin, David Bertoch, and Anthony D. Slonim
Arch Pediatr Adolesc Med. 2007;161(3):282-290.
ABSTRACT
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