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Arch Pediatr Adolesc Med. 2007;161(11):1103.

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Denouement and Discussion: Blueberry Muffin Baby (Extramedullary Hematopoiesis) Due to Congenital Cytomegalovirus Infection

Nasopharyngeal, conjunctival, and urine viral cultures grew cytomegalovirus (CMV). Blood CMV pp65 antigenemia was detected at a level of 58/200 000 cells and IgG to CMV was detected. The child was treated for 6 weeks with ganciclovir, and the cutaneous findings slowly faded over 3 to 4 weeks. Initial hearing screen results were normal.

Blueberry muffin baby is a term used to describe a purplish or bluish-red maculopapular rash present at birth, typically on the face, neck, and trunk.¹ Traditionally, it has been used to describe the cutaneous findings of congenital rubella, but other conditions can produce the same skin findings. The differential diagnosis of blueberry muffin baby includes conditions associated with dermal extramedullary hematopoiesis, infiltrative neoplastic lesions of the skin, and cutaneous vascular anomalies. Rarely do new lesions appear after birth. In most cases, the lesions evolve into tan macules and fade completely within a few weeks. When lesions do . . . [Full Text of this Article]

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Arch Pediatr Adolesc Med. 2007;161(11):1102.
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