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Diphenhydramine in Infants—Reply
Dan Merenstein, MD;
Marie Diener-West, PhD;
Ann C. Halbower, MD;
Alex Krist, MD, MPH;
Haya R. Rubin, MD, PhD
Arch Pediatr Adolesc Med. 2007;161(1):105.
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In reply
I appreciate Dr Simon's reply regarding our study. We agree that medication prescribing in young children is too often based on anecdote and experience rather than evidence. However, in our experience, the lack of evidence on medications for children is partly because of the obstacles in conducting pediatric research. It is important to take proper precautions when conducting studies on children, but at times insitutional review boards, funding agencies, or physicians would rather use untested medications on children rather than encouraging quality research in controlled settings. At present, one of the most common problems new parents face, childhood sleep disorders, has few well-conducted randomized controlled studies. Although Congress passed the Pediatric Research Equity Act of 2003, which was endorsed by both the Centers for Medicare & Medicaid Services commissioner . . . [Full Text of this Article] AUTHOR INFORMATION
RELATED LETTER
Diphenhydramine in Infants
F. Estelle R. Simons
Arch Pediatr Adolesc Med. 2007;161(1):105.
EXTRACT
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RELATED ARTICLE
The Trial of Infant Response to Diphenhydramine: The TIRED Study—A Randomized, Controlled, Patient-Oriented Trial
Dan Merenstein, Marie Diener-West, Ann C. Halbower, Alex Krist, and Haya R. Rubin
Arch Pediatr Adolesc Med. 2006;160(7):707-712.
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