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Arch Pediatr Adolesc Med. 2006;160:802.

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Denouement and Discussion: Stevens-Johnson Syndrome

On the basis of the clinical findings, a diagnosis of Stevens-Johnson syndrome was made. The cause was identified to be a nonsteroidal anti-inflammatory drug, nabumetone, that the patient had begun taking 4 days before the skin eruption occurred for muscle soreness after a motor vehicle crash. Nabumetone administration was discontinued.

The patient was transferred to the intensive care unit for fluid resuscitation and pain control. Intravenous immunoglobulin was initiated at a dosage of 0.7 g/kg per day for 3 days. The patient's general condition stabilized. After 24 hours, new skin lesions stopped appearing. The lesions that were already present resolved over the following 3 to 4 weeks. The patient was discharged on hospital day 8 in good health with no sequelae.

Stevens-Johnson syndrome is a severe reactive condition affecting skin and mucosal surfaces. By definition, Stevens-Johnson syndrome has extensive skin involvement accompanied by erosions of at least 2 mucosal surfaces. . . . [Full Text of this Article]

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