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Alternating Acetaminophen and Ibuprofen in Children May Cause Parental Confusion and Is Dangerous—Reply
Arch Pediatr Adolesc Med. 2006;160:757-758.
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In reply
We disagree with the comments made by Dr Saphyakhajon concerning the possible confusion of using both antipyretics in children with fever and their possible adverse effects in the doses studied. Furthermore, we disagree with Dr Schmitt that dual therapy will increase parents' preoccupation with "controlling the fever" and increase fever phobia.
The recent study alternating acetaminophen and ibuprofen was prompted by parental concern with their child's fever, their confusion over the dosage and frequency of administration, and the fact that both medications are readily available and are widely used.1 Studies have reported that 50% or more parents or caregivers administer both antipyretics to their children but their methods of alternation vary.2 Furthermore, in about half the cases, the dose used is inaccurate.3 We chose the dosages of 12.5 mg/kg of acetaminophen per dose (of 125 mg per 5 cm3) alternating with 5 mg/kg of ibuprofen per dose . . . [Full Text of this Article] AUTHOR INFORMATION
E. Michael Sarrell, MD;
Eliahu Wielunsky, MD;
Herman Avner Cohen, MD
RELATED LETTER
Alternating Acetaminophen and Ibuprofen in Children May Cause Parental Confusion and Is Dangerous
Phisit Saphyakhajon and Gerald Greene
Arch Pediatr Adolesc Med. 2006;160(7):757.
EXTRACT
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RELATED ARTICLE
Antipyretic Treatment in Young Children With Fever: Acetaminophen, Ibuprofen, or Both Alternating in a Randomized, Double-blind Study
E. Michael Sarrell, Eliahu Wielunsky, and Herman Avner Cohen
Arch Pediatr Adolesc Med. 2006;160(2):197-202.
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