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Alternating Acetaminophen and Ibuprofen in Children May Cause Parental Confusion and Is Dangerous
Arch Pediatr Adolesc Med. 2006;160:757.
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We are concerned about "Antipyretic Treatment in Young Children With Fever: Acetaminophen, Ibuprofen, or Both Alternating in a Randomized, Double-Blind Study" reported by Sarrell et al1 in the February issue of the ARCHIVES. The alternating of acetaminophen and ibuprofen for treating fever in children may cause parental confusion. The parent may give the child acetaminophen, acetaminophen, ibuprofen, ibuprofen rather than acetaminophen, ibuprofen, acetaminophen, ibuprofen.
The treatment may also be dangerous. One case report describes a 14-month-old, previously healthy girl who was admitted for febrile status epilepticus. Her seizure was controlled and her clinical course was improved, but she continued to have a fever. On hospital day 6, the patient spiked a temperature of 105.0°. An alternating regimen of acetaminophen and ibuprofen was initiated. On day 8 of hospitalization, she developed acute renal failure.
After a thorough renal investigation, the authors suggested that the combination of acetaminophen and ibuprofen . . . [Full Text of this Article] AUTHOR INFORMATION
Phisit Saphyakhajon, MD;
Gerald Greene, MD, MPH
RELATED LETTER
Alternating Acetaminophen and Ibuprofen in Children May Cause Parental Confusion and Is Dangerous—Reply
E. Michael Sarrell, Eliahu Wielunsky, and Herman Avner Cohen
Arch Pediatr Adolesc Med. 2006;160(7):757-758.
EXTRACT
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RELATED ARTICLE
Antipyretic Treatment in Young Children With Fever: Acetaminophen, Ibuprofen, or Both Alternating in a Randomized, Double-blind Study
E. Michael Sarrell, Eliahu Wielunsky, and Herman Avner Cohen
Arch Pediatr Adolesc Med. 2006;160(2):197-202.
ABSTRACT
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