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Arch Pediatr Adolesc Med. 2006;160:646.

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Denouement and Discussion: Calcified Nodule Secondary to Heel Sticks

The first association between heel sticks to draw blood in the neonatal period and the development of calcified nodules of the heel was made by O’Doherty¹ and has since been fairly well-recognized in the neonatology community. Most reports of this entity have described it in association with high-risk neonates receiving multiple heel sticks in the nursery. However, more recently, Leung² and Rho et al³ reported cases occurring following a single heel stick in healthy neonates.

Lesions may be multiple or solitary, white or yellowish verrucous papules or nodules, which are firm and often tender.^1-10 Typically, the lesions appear 4 to 12 months after birth^4-7 as multiple tiny specks that gradually enlarge and either persist or spontaneously extrude through the epidermis. Spontaneous resolution may occur within 18 to 30 months,^4-5,7-8 yet recurrence following removal with curettage has been reported.⁶ Although previously thought to be largely asymptomatic, a protracted course with discomfort . . . [Full Text of this Article]

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Arch Pediatr Adolesc Med. 2006;160(6):645.
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