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Incidence of Autism—Reply
Arch Pediatr Adolesc Med. 2005;159:691-692.
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In reply
Dr Fischer's letter highlights the difficulties in interpreting ecologic trends in studies such as this, namely, the potential association between the introduction of a new strain of measles vaccine, the change to a 2-dose MMR vaccination schedule, and the increase in the incidence of autism between 1976 and 1997 reported in our study.1
Dr Fischer is correct in noting that the RA 27/3 vaccine virus strain was introduced in 1979.2 This vaccine virus strain was quickly adopted throughout the world, with the exception of Japan. However, the apparent change in the incidence of autism in Olmsted County, Minnesota, was not observed until 1988 to 1991, approximately 10 years after the introduction of this new vaccine virus strain.
It is reasonable to ask whether the introduction of a revaccination with a second dose of MMR vaccine, using the RA 27/3 virus strain, was associated with the observed change in . . . [Full Text of this Article] AUTHOR INFORMATION
William J. Barbaresi, MD;
Slavica K. Katusic, MD;
Robert C. Colligan, PhD;
Amy L. Weaver, MS;
Steven J. Jacobsen, MD, PhD
RELATED ARTICLE
Incidence of Autism
Frank Fischer, Jr
Arch Pediatr Adolesc Med. 2005;159(7):691.
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