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Arch Pediatr Adolesc Med. 2005;159:690-691.

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In reply

We thank Drs Yarborough and Erdreich for their interest in our study, as well as in our previous studies.

In their criticism, they reiterate limitations we explicitly acknowledge in the article, including sample size, lack of dose response, multiple chemicals, and potential selection bias, to mention a few. Yet, to our knowledge, this is the first prospective controlled study to have done such analysis, controlling for maternal socioeconomic class, IQ, education, and family income. Naturally, there will never be a randomized trial in this area, to the extent possible, and any observational study has the risk of uncontrolled, unknown confounders. We believe our study controlled for confounders of neurodevelopment by measuring maternal IQ, education, and family income.

Peculiarly, after reading our article, Yarborough and Erdreich have concluded that "the study was based on participants in a program that provides education about pregnancy-related risks of drugs and chemicals." This . . . [Full Text of this Article]

AUTHOR INFORMATION

Gideon Koren, MD

RELATED ARTICLE

Child Neurocognitive and Behavioral Outcomes and Maternal Solvent Exposure During Pregnancy
Charles M. Yarborough and Linda Erdreich
Arch Pediatr Adolesc Med. 2005;159(7):690.
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