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Arch Pediatr Adolesc Med. 2005;159:690.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The study by Laslo-Baker et al¹ reports poorer performance on some specific neurocognitive and behavioral outcomes among children whose mothers reported solvent exposures during pregnancy. However, the authors do not discuss important limitations of this study that preclude reaching cause-and-effect conclusions, specifically, the small size and questionable representativeness of the study populations, the limitations of the exposure assessment, the potential for both uncontrolled and residual confounding, and multiple comparisons with selective presentation of results.

The study was based on participants in a program that provides education about the pregnancy-related risks of drugs and chemicals. Of the 226 mothers who reported exposures to solvents at work, only 32 were recruited. There were more refusals (50) than participants among the exposed group, and no information was provided on how the unexposed were selected or their participation rates. In addition, there was questionable exclusion of 26 subjects (Table 1) after testing because presumed . . . [Full Text of this Article]

AUTHOR INFORMATION

Charles M. Yarborough, MD, MPH; Linda Erdreich, PhD

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Child Neurocognitive and Behavioral Outcomes and Maternal Solvent Exposure During Pregnancy—Reply
Gideon Koren
Arch Pediatr Adolesc Med. 2005;159(7):690-691.
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