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Coinfection With Hepatitis C Virus and Human Immunodeficiency Virus 1 in Children: Pathogenesis and Screening—Reply
Arch Pediatr Adolesc Med. 2005;159:599.
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In reply
We appreciate the comments of Dr Soudeyns and colleagues and would like to address their concerns. The PACTG 1028S study was designed to determine the prevalence of HCV infection in a large cohort of perinatally HIV-infected children. We agree that HCV testing of the entire 219C population would have been ideal; however, this was not feasible. To get a representative sample of the 219C population, subjects were randomly selected to participate in 1028S. We did not include HIV-infected children younger than 1 year to exclude children with maternally transmitted HCV antibody because both enzyme immunoassay and RNA testing (reverse transcription polymerase chain reaction) were performed on all study participants. As Dr Soudeyns and colleagues correctly state, normal aminotransferase levels may be seen in pediatric HCV infection. Although historical medical information regarding liver disease, jaundice, and hepatitis A and/or B infection was obtained for all study participants, serum aminotransferase . . . [Full Text of this Article] AUTHOR INFORMATION
Susan J. Schuval, MD
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Coinfection With Hepatitis C Virus and Human Immunodeficiency Virus 1 in Children: Pathogenesis and Screening
Steven R. Martin, Normand Lapointe, and Hugo Soudeyns
Arch Pediatr Adolesc Med. 2005;159(6):598-599.
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