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Risk of Mania With Antidepressants
Arch Pediatr Adolesc Med. 2005;159:298.
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In their report on age effects on risk of antidepressant treatment–associated mania, Martin et al1 found that children, adolescents, and young adults treated for depressive or anxiety disorders showed an increased risk of new-onset mania at ages 15 to 25 years. Rates of "conversion" to bipolar disorder (new mania) were lowest in children aged 5 to 9 years and similarly intermediate in those aged 10 to 14 years and 25 to 29 years. They also found a nearly 2-fold greater overall risk of mania with tricyclic antidepressants (TCAs) (hazard ratio vs no antidepressant exposure, 3.9) than with serotonin reuptake inhibitors (SRIs) (hazard ratio, 2.1).
We reanalyzed their data (Table 3)1(p779) concerning risks of mania with SRIs, TCAs, all antidepressants, and no antidepressant treatment vs age. The findings (Figure) indicate an elevated risk of new mania at ages 5 to 19 years with any antidepressant treatment and a particularly . . . [Full Text of this Article] AUTHOR INFORMATION
Ross J. Baldessarini, MD;
Gianni L. Faedda, MD;
John Hennen, PhD
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Arch Pediatr Adolesc Med. 2005;159(3):298-299.
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