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Arch Pediatr Adolesc Med. 2005;159:197.

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In reply

We appreciate Drs Barbi, Faleschini, and Bassanese raising the issue of treatment of children with severe bronchiolitis and the possible role of surfactant therapy. Our article¹ was based on a comprehensive systematic review of the diagnosis and treatment of bronchiolitis in infants and children. The full report is available elsewhere, as detailed in our article; however, in the February 2004 issue of the ARCHIVES, only detailed results for the most commonly used pharmacologic agents are presented, and we specifically excluded surfactant and other less common interventions. Our complete review identified 1 randomized controlled trial of surfactant therapy that met our inclusion criteria.² Luchetti et al² conducted a small study of 20 infants with severe bronchiolitis. The treatment group received 50 mg/kg of porcine-derived surfactant instilled into the trachea in 2 to 3 doses. Both the control and treatment groups received continuous positive pressure ventilation and other . . . [Full Text of this Article]

AUTHOR INFORMATION

Valerie J. King, MD, MPH; W. Clayton Bordley, MD, MPH; Meera Viswanathan, PhD

RELATED ARTICLE

Do We Really Need More Trials About the Efficacy of Commonly Used Treatments for Bronchiolitis?
Egidio Barbi, Elena Faleschini, and Stefania Bassanese
Arch Pediatr Adolesc Med. 2005;159(2):196-197.
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