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Interpreting Subgroup Analyses
Is a School-Based Asthma Treatment Program's Effect Modified by Secondhand Smoke Exposure?
Arch Pediatr Adolesc Med. 2004;158:469-471.
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Halterman et al1 present a randomized controlled trial (RCT) of a school-based asthma treatment program in this issue of the ARCHIVES. The authors enrolled 184 children with asthma 3 to 7 years of age from 1 school district. Children were identified via a school health form and were eligible for enrollment if at least mild persistent asthma was confirmed and the primary care physician (PCP) agreed with the need for daily inhaled steroids. After obtaining consent from the family and PCP and completing a baseline assessment, eligible children were randomized to the school-based intervention or control group. In both groups, parents and PCPs were notified of the child's asthma severity. On weekdays, school nurses administered study-provided inhaled steroids to the intervention group children; a second steroid inhaler was given to families for home use on nonschool days. Inhaled steroids were recommended but neither provided nor directly administered . . . [Full Text of this Article]VALIDITY
Randomization Accounting for Subjects Blinding Equal Treatment of Groups, Aside From the Intervention TREATMENT EFFECT
GENERALIZABILITY
SUBGROUP ANALYSIS Source of Comparisons
Hypothesized Subgroup Effects Effect Size Indirect Evidence CONCLUSIONS
David G. Bundy, MD, MPH;
Molly Curtin Berkoff, MD, MPH;
Kristin E. Ito, MD;
Marjorie S. Rosenthal, MD;
Morris Weinberger, PhD
Chapel Hill, NC
RELATED ARTICLE
Benefits of a School-Based Asthma Treatment Program in the Absence of Secondhand Smoke Exposure: Results of a Randomized Clinical Trial
Jill S. Halterman, Peter G. Szilagyi, H. Lorrie Yoos, Kelly M. Conn, Jeffrey M. Kaczorowski, Robert J. Holzhauer, Sherri C. Lauver, Tia L. Neely, Patrick M. Callahan, and Kenneth M. McConnochie
Arch Pediatr Adolesc Med. 2004;158(5):460-467.
ABSTRACT
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