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Arch Pediatr Adolesc Med. 2003;157:1241-1242.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In 1963, Reye and associates¹ described a syndrome in 21 children, characterized by acute encephalopathy, hepatic steatosis, and elevated levels of serum transaminases. Subsequent studies in the 1960s and 1970s revealed that it was a virus-related illness mainly associated with antecedent influenza B and varicella virus infections. In 1977, 454 cases of Reye syndrome were reported in the United States, and of 373 cases with follow-up, 42% died and 11% had residual neurologic damage.² In the late 1970s and early 1980s, a number of case-control studies described an association between aspirin ingestion and the development of Reye syndrome.³ The Committee of Infectious Disease of the American Academy of Pediatrics and the Centers for Disease Control and Prevention recommended that aspirin-containing products not be given to children. In 1986, a warning label was required for all aspirin-containing products sold in the United States. In the last 2 decades, reported Reye syndrome . . . [Full Text of this Article]

Emilie L. Chow, MD
Department of Pediatrics
Mattel Children Hospital
10833 Le Conte Ave, Box 951752
Los Angeles, CA 90095-1752
(echow@mednet.ucla.edu)

James D. Cherry, MD; Rick Harrison, MD; Sue V. McDiarmid, MD; Sunita Bhuta, MD
Los Angeles