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Predicting Neonatal Brain Injury
Are We There Yet?
Arch Pediatr Adolesc Med. 2003;157:1151-1152.
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HYPOXIC ISCHEMIC encephalopathy (HIE) is an important clinical problem in perinatal medicine. Until recently, very little could be done to prevent the devastating sequelae of this condition. Recent advances such as cooling strategies hold promise in this field but they require early identification and intervention.1-2 It still remains difficult to predict which infants will have long-term neurologic sequelae from HIE.3-4 Having a useful marker for a poor neurologic outcome is urgently needed. In the article by Gazzolo et al,5 urinary S100B protein concentrations are used as a marker for brain damage in asphyxiated infants.
The biological role of S100B protein, a calcium-binding protein found in the nervous system, is still unclear. It is secreted by astrocytes and may affect nerve growth or regeneration.6 The S100B protein concentration is regulated through serotoninergic transmission and stimulates neurite outgrowth and enhances survival of neurons7; therefore, S100B protein could be considered a protective . . . [Full Text of this Article]
Phyllis A. Dennery, MD
Department of Pediatrics
Stanford University
750 Welch Rd, Room 315
Palo Alto, CA 94304
RELATED ARTICLE
Measurement of Urinary S100B Protein Concentrations for the Early Identification of Brain Damage in Asphyxiated Full-term Infants
Diego Gazzolo, Emanuela Marinoni, Romolo Di Iorio, Matteo Bruschettini, Maria Kornacka, Mario Lituania, Urszula Majewska, Giovanni Serra, and Fabrizio Michetti
Arch Pediatr Adolesc Med. 2003;157(12):1163-1168.
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