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Do Polymorphisms of the Interleukin 1 Gene Cluster Simplify Our Understanding?

Arch Pediatr Adolesc Med. 2002;156:529-530.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

FEBRILE SEIZURES are among the most common pediatric neurological problems, affecting approximately 2% to 5% of all children.¹ Febrile seizures usually present between 6 months and 5 years of age¹ and are classified as simple if they occur with rise of temperature, last 15 minutes or less, and are not followed by postictal paralysis, neurological deficit, or an abnormal interictal electroencephalogram. Simple febrile seizures are equally common in boys and girls and often run in families. The genetic susceptibility to febrile seizures seems to involve multiple genes in most instances.² But what are those genes? Some forms of familial epilepsy may initially present as simple febrile seizures, and several of these disorders are due to defined genetic causes such as deficiencies of neuronal sodium channels³ or GABA receptors.⁴ However, it is not known if polymorphisms in those genes involved in familial epilepsies also contribute to the pathogenesis of simple febrile . . . [Full Text of this Article]

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Polymorphisms for Interleukin 1ß Exon 5 and Interleukin 1 Receptor Antagonist in Taiwanese Children With Febrile Convulsions
Fuu-Jen Tsai, Yao-Yuan Hsieh, Chi-Chen Chang, Cheng-Chieh Lin, and Chang-Hai Tsai
Arch Pediatr Adolesc Med. 2002;156(6):545-548.
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