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The Problem and Some Suggestions

Arch Pediatr Adolesc Med. 2002;156:424-425.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

IN THIS issue of the ARCHIVES, Klassen et al¹ contribute an interesting article on the problem of publication bias. They examined abstracts presented at Society for Pediatric Research meetings from 1992 through 1995 and found that only 59% of randomized controlled trials presented at the meetings were subsequently published. Abstracts were more likely to be published as a full study if, using some criteria for statistical significance, they either reported that the outcomes of the treated group were superior to those of the control group or reported that a newer therapy was at least equivalent to an older treatment. To rephrase this in the other direction, studies were more often sent to oblivion if they failed to report good news about newer therapies.

The study by Klassen et al has important implications for how research is conducted, published, and interpreted. Conscientious physicians who seek the best therapy based on published . . . [Full Text of this Article]

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